{"id":1178,"date":"2026-10-20T16:06:52","date_gmt":"2026-10-20T08:06:52","guid":{"rendered":"https:\/\/orthojiunliang.tw\/?page_id=1178"},"modified":"2026-10-20T16:06:52","modified_gmt":"2026-10-20T08:06:52","slug":"publications","status":"publish","type":"page","link":"https:\/\/orthojiunliang.tw\/en\/publications\/","title":{"rendered":"Research &#038; Publications"},"content":{"rendered":"\n<style>body:has(.jl-news-header) .elementor-location-header{display:none!important}\n.jl-news .jl-news-header{max-width:1440px;margin:0 auto;padding:24px 4.7% 0;background:#fff}\n.jl-news .jl-nav{display:flex;align-items:center;justify-content:space-between;gap:22px;background:#fff;border:1px solid #dce4eb;border-radius:50px;padding:14px 25px;position:relative;z-index:3;color:#435766}\n.jl-news .jl-logo{display:block;position:relative;flex:0 0 188px;height:44px}\n.jl-news .jl-logo img{position:absolute;left:0;top:0;width:142px;height:44px;max-width:none;clip-path:inset(0 69% 0 0)}\n.jl-news .jl-logo::before{content:\"\u9673\u4fca\u826f\u91ab\u5e2b\";position:absolute;left:54px;top:0;font-size:20px;line-height:1.4;letter-spacing:.06em;font-weight:600;color:#102d49}\n.jl-news .jl-logo::after{content:\"CHEN JIUN LIANG\";position:absolute;left:54px;bottom:0;font-family:Arial,sans-serif;font-size:11px;line-height:1.4;letter-spacing:.06em;color:#4c687e;white-space:nowrap}\n.jl-news .jl-navlinks{display:flex;gap:22px;align-items:center;font-size:14px;white-space:nowrap}\n.jl-news .jl-navlinks a{min-height:44px;display:flex;align-items:center}\n.jl-news .jl-navlinks a[aria-current]{color:#327a98;font-weight:600}\n.jl-news .jt-intro{padding-top:48px}\n@media(max-width:820px){.jl-news .jl-nav{padding:12px 20px;gap:14px}.jl-news .jl-navlinks{gap:13px;font-size:12px}}\n@media(max-width:620px){.jl-news .jl-news-header{padding:16px 20px 0}.jl-news .jl-nav{border-radius:16px;flex-wrap:wrap;justify-content:center;gap:9px;padding:14px 10px 10px}.jl-news .jl-navlinks{width:100%;gap:0;justify-content:space-around;white-space:normal;text-align:center;font-size:11px}.jl-news .jl-navlinks a{padding:6px 3px;min-height:44px;display:flex;align-items:center;justify-content:center}.jl-news .jt-intro{padding-top:36px}}\n@media(max-width:355px){.jl-news .jl-news-header{padding-left:14px;padding-right:14px}}\n\n\n.jl-news{font-family:\"PingFang TC\",Arial,sans-serif}.jl-news a{color:inherit;text-decoration:none}\nbody:has(.jr-page) .page-header{display:none}body:has(.jr-page) main#content{max-width:none;width:100%;padding:0}\n.jr-page{max-width:1100px;width:calc(100% - 48px);margin:auto;color:#12304b;font:17px\/1.85 Arial,\"PingFang TC\",sans-serif;padding-bottom:55px}\n.jr-page *{box-sizing:border-box}.jr-page a{color:#286984;text-underline-offset:4px}.jr-page a:focus-visible{outline:3px solid #347e9b;outline-offset:4px}\n.jr-hero{padding:64px 0 35px;border-bottom:1px solid #d8e3ec;background:linear-gradient(135deg,transparent 82%,#dce7ee 82.1%,transparent 82.3%)}\n.jr-eye{color:#42728c;font-size:13px;letter-spacing:.16em}.jr-hero h1{font-size:clamp(31px,4vw,48px);line-height:1.25;color:#12304b;margin:14px 0 22px}\n.jr-hero p{max-width:750px}.jr-years{display:flex;gap:12px;flex-wrap:wrap;margin:25px 0}.jr-years a{border:1px solid #bccfdd;border-radius:6px;padding:7px 17px;text-decoration:none;font-size:14px}\n.jr-paper{display:grid;grid-template-columns:90px minmax(0,1fr);gap:30px;padding:36px 0;border-bottom:1px solid #d8e3ec;scroll-margin-top:30px}\n.jr-year{font-size:29px;color:#6c8da3}.jr-paper h2{font-size:25px;line-height:1.4;color:#12304b;margin:7px 0 13px}.jr-type{font-size:12px;color:#34708b;letter-spacing:.04em}\n.jr-title{font-size:16px;font-weight:600;line-height:1.6;margin:0 0 9px}.jr-citation{font-size:13px;color:#63798a;margin:0 0 18px}\n.jr-summary{color:#425e72;font-size:16px}.jr-links{display:flex;gap:12px;flex-wrap:wrap;margin:19px 0 13px}.jr-links a{border:1px solid #b9cedd;padding:8px 14px;border-radius:6px;text-decoration:none;font-size:14px}.jr-links a:first-child{background:#12304b;color:#fff;border-color:#12304b}\n.jr-license{color:#657b8d;font-size:12px}.jr-note{padding:19px 23px;background:#f1f6f9;margin-top:30px;font-size:14px;color:#526d81}\n@media(max-width:650px){.jr-page{width:calc(100% - 40px);font-size:16px}.jr-hero{padding-top:36px}.jr-paper{grid-template-columns:1fr;gap:5px;padding:28px 0}.jr-year{font-size:17px}.jr-paper h2{font-size:23px}.jr-links a{width:100%;text-align:center}}\n<\/style><div class=\"jl-news\"><header class=\"jl-news-header\"><nav class=\"jl-nav\" aria-label=\"\u7db2\u7ad9\u5c0e\u89bd\">\n        <a class=\"jl-logo\" aria-label=\"\u9673\u4fca\u826f\u91ab\u5e2b CHEN JIUN LIANG\" href=\"https:\/\/orthojiunliang.tw\/\"><img src=\"https:\/\/orthojiunliang.tw\/wp-content\/uploads\/Frame-1171277234-300x93-1.png\" decoding=\"async\" loading=\"eager\" alt=\"\u9673\u4fca\u826f\u91ab\u5e2b CHEN JIUN LIANG\" width=\"300\" height=\"93\"><\/a>\n        <div class=\"jl-navlinks\">\n          <a href=\"https:\/\/orthojiunliang.tw\/\">\u9996\u9801<\/a>\n          <a href=\"https:\/\/orthojiunliang.tw\/about\/\">\u9673\u4fca\u826f\u91ab\u5e2b<\/a>\n          <a href=\"https:\/\/orthojiunliang.tw\/services\/\">\u6cbb\u7642\u9805\u76ee<\/a>\n          <a href=\"https:\/\/orthojiunliang.tw\/news\/\">\u6700\u65b0\u6d88\u606f<\/a>\n          <a href=\"https:\/\/orthojiunliang.tw\/faq\/\">\u5e38\u898b\u554f\u984c<\/a>\n        <\/div>\n      <\/nav><\/header><\/div><section class=\"jr-page\" lang=\"en\" data-no-translation><header class=\"jr-hero\"><p class=\"jr-eye\">CHEN JIUN LIANG \u00b7 ORTHOPAEDIC RESEARCH<\/p><h1>Research &amp; Publications<\/h1><p>Selected publications on joint replacement infections, fracture care and bone health. Explore concise English summaries, original journal records and available full-text papers.<\/p><nav class=\"jr-years\" aria-label=\"Publication years\"><a href=\"#research-2022\">2022<\/a><a href=\"#research-2021\">2021<\/a><a href=\"#research-2018\">2018<\/a><a href=\"#research-2017\">2017<\/a><\/nav><\/header><article class=\"jr-paper\" id=\"research-2022\"><div class=\"jr-year\">2022<\/div><div><div class=\"jr-type\">Retrospective case series<\/div><h2>Rare Pseudomonas Infections in Necrotizing Fasciitis<\/h2><p class=\"jr-title\">Monomicrobial Necrotizing Fasciitis and Sepsis Caused by Pseudomonas aeruginosa and Pseudomonas fluorescens: a Series of Ten Cases<\/p><p class=\"jr-citation\">Chen JL, Huang TY, Kuo LT, Huang KC, Tsai YH. Japanese Journal of Infectious Diseases. 2022;75(6):554-559.<br>DOI: 10.7883\/yoken.JJID.2022.087<\/p><p class=\"jr-summary\">This retrospective series examined ten patients with necrotizing fasciitis caused by Pseudomonas species. Two patients died. The study describes clinical presentations and laboratory differences between survivors and nonsurvivors, highlighting the seriousness of this uncommon infection. Its small sample limits how broadly the findings can be applied.<\/p><div class=\"jr-links\"><a href=\"https:\/\/www.jstage.jst.go.jp\/article\/yoken\/75\/6\/75_JJID.2022.087\/_pdf\/-char\/en\" target=\"_blank\" rel=\"noopener\">Read original PDF \u2197<\/a><a href=\"https:\/\/www.jstage.jst.go.jp\/article\/yoken\/75\/6\/75_JJID.2022.087\/_article\/-char\/en\" target=\"_blank\" rel=\"noopener\">Journal \/ source \u2197<\/a><\/div><div class=\"jr-license\">Full text is provided through the original publisher where available.<\/div><\/div><\/article><article class=\"jr-paper\"><div class=\"jr-year\">2022<\/div><div><div class=\"jr-type\">Clinical isolate and laboratory study<\/div><h2>Understanding MRSA in Joint Replacement Infections<\/h2><p class=\"jr-title\">Characterization of Methicillin-Resistant Staphylococcus aureus Isolates from Periprosthetic Joint Infections<\/p><p class=\"jr-citation\">Chen JL, Huang TY, Hsu WB, Lee CW, Chiang YC, Chang PJ, Peng KT. Pathogens. 2022;11(7):719.<br>DOI: 10.3390\/pathogens11070719<\/p><p class=\"jr-summary\">Researchers analysed 36 MRSA isolates from patients with periprosthetic joint infections, comparing genetic types, antibiotic susceptibility and biofilm formation. ST239 isolates showed greater biofilm formation and resistance to several antibiotics, alongside more pronounced inflammatory findings in affected patients. The results describe local bacterial diversity and support further study of genotype-informed infection management.<\/p><div class=\"jr-links\"><a href=\"https:\/\/orthojiunliang.tw\/wp-content\/uploads\/chen-2022-mrsa-periprosthetic-joint-infection.pdf\" target=\"_blank\" rel=\"noopener\">Read original PDF \u2197<\/a><a href=\"https:\/\/www.mdpi.com\/2076-0817\/11\/7\/719\" target=\"_blank\" rel=\"noopener\">Journal \/ source \u2197<\/a><\/div><div class=\"jr-license\">\u00a9 2022 the authors. CC BY 4.0. Original publisher PDF; unchanged. <a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" target=\"_blank\" rel=\"noopener\">License<\/a><\/div><\/div><\/article><article class=\"jr-paper\"><div class=\"jr-year\">2022<\/div><div><div class=\"jr-type\">Population-based observational study<\/div><h2>Subsequent Fractures and Mortality in Taiwan<\/h2><p class=\"jr-title\">Incidence of different types of subsequent fractures and related mortality in Taiwan<\/p><p class=\"jr-citation\">Chen JL, Tai TW, Chou CY, et al. Archives of Osteoporosis. 2022;17:55.<br>DOI: 10.1007\/s11657-022-01098-6<\/p><p class=\"jr-summary\">Using Taiwan&#x27;s health insurance data, this study followed adults aged 50 and older after an initial fracture. It compared subsequent fracture patterns and associated mortality across fracture sites. Patients whose first fracture involved the hip had the highest subsequent-fracture incidence, underscoring the importance of secondary fracture prevention. The observational design identifies associations rather than proving causation.<\/p><div class=\"jr-links\"><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11657-022-01098-6\" target=\"_blank\" rel=\"noopener\">Journal \/ source \u2197<\/a><\/div><div class=\"jr-license\">Full text is provided through the original publisher where available.<\/div><\/div><\/article><article class=\"jr-paper\" id=\"research-2021\"><div class=\"jr-year\">2021<\/div><div><div class=\"jr-type\">Prospective clinical study<\/div><h2>Pathogens and Risk Indicators in Necrotizing Fasciitis<\/h2><p class=\"jr-title\">Bacteriology and mortality of necrotizing fasciitis in a tertiary coastal hospital with comparing risk indicators of methicillin-resistant Staphylococcus aureus and Vibrio vulnificus infections: a prospective study<\/p><p class=\"jr-citation\">Tsai YH, Huang TY, Chen JL, Hsiao CT, Kuo LT, Huang KC. BMC Infectious Diseases. 2021;21:771.<br>DOI: 10.1186\/s12879-021-06518-5<\/p><p class=\"jr-summary\">This prospective study followed 184 patients with necrotizing fasciitis at a coastal hospital. It compared pathogen profiles, clinical features and outcomes, including differences between MRSA and Vibrio vulnificus infections. Shock and bloodstream infection were more common among patients who died. The findings emphasise that infection patterns and risk indicators vary by organism and clinical setting.<\/p><div class=\"jr-links\"><a href=\"https:\/\/orthojiunliang.tw\/wp-content\/uploads\/tsai-2021-necrotizing-fasciitis.pdf\" target=\"_blank\" rel=\"noopener\">Read original PDF \u2197<\/a><a href=\"https:\/\/link.springer.com\/article\/10.1186\/s12879-021-06518-5\" target=\"_blank\" rel=\"noopener\">Journal \/ source \u2197<\/a><\/div><div class=\"jr-license\">\u00a9 2021 the authors. CC BY 4.0. Original publisher PDF; unchanged. <a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" target=\"_blank\" rel=\"noopener\">License<\/a><\/div><\/div><\/article><article class=\"jr-paper\"><div class=\"jr-year\">2021<\/div><div><div class=\"jr-type\">Preclinical laboratory and mouse study<\/div><h2>Immune Regulation in Experimental Joint Infection<\/h2><p class=\"jr-title\">GMI, an Immunomodulatory Peptide from Ganoderma microsporum, Restrains Periprosthetic Joint Infections via Modulating the Functions of Myeloid-Derived Suppressor Cells and Effector T Cells<\/p><p class=\"jr-citation\">Peng KT, Chen JL, Kuo LT, Yu PA, Hsu WH, Lee CW, Chang PJ, Huang TY. International Journal of Molecular Sciences. 2021;22(13):6854.<br>DOI: 10.3390\/ijms22136854<\/p><p class=\"jr-summary\">This preclinical study investigated how GMI affects immune cells in experimental Staphylococcus aureus joint infection. Laboratory experiments and a mouse model showed changes in suppressor-cell accumulation and T-cell activity. These findings suggest a research direction for infection treatment; they do not establish that GMI is an effective or approved treatment for patients with joint replacement infections.<\/p><div class=\"jr-links\"><a href=\"https:\/\/orthojiunliang.tw\/wp-content\/uploads\/peng-2021-gmi-preclinical-study.pdf\" target=\"_blank\" rel=\"noopener\">Read original PDF \u2197<\/a><a href=\"https:\/\/www.mdpi.com\/1422-0067\/22\/13\/6854\" target=\"_blank\" rel=\"noopener\">Journal \/ source \u2197<\/a><\/div><div class=\"jr-license\">\u00a9 2021 the authors. CC BY 4.0. Original publisher PDF; unchanged. <a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" target=\"_blank\" rel=\"noopener\">License<\/a><\/div><\/div><\/article><article class=\"jr-paper\"><div class=\"jr-year\">2021<\/div><div><div class=\"jr-type\">Preprint \u00b7 Retrospective clinical series<\/div><h2>Looking Beyond the Hip in Recurrent Joint Infection<\/h2><p class=\"jr-title\">Recalcitrant Periprosthetic Joint Infection With Iliac Fossa Abscess After Total Hip Arthroplasty<\/p><p class=\"jr-citation\">Peng KT, Huang TY, Chen JL, Lee CW, Shih HN. Research Square. Posted January 21, 2021. Version 1.<br>DOI: 10.21203\/rs.3.rs-144908\/v1<\/p><p class=\"jr-summary\">This preprint describes seven patients with iliac fossa abscess identified during a review of 256 hip prosthetic joint infection cases. It examines imaging and combined surgical approaches used to address infection extending beyond the joint. The findings are preliminary, based on a small uncontrolled series, and should not be presented as a peer-reviewed treatment recommendation.<\/p><div class=\"jr-links\"><a href=\"https:\/\/orthojiunliang.tw\/wp-content\/uploads\/peng-2021-iliac-fossa-abscess-preprint-v1.pdf\" target=\"_blank\" rel=\"noopener\">Read preprint PDF \u2197<\/a><a href=\"https:\/\/www.researchsquare.com\/article\/rs-144908\/v1\" target=\"_blank\" rel=\"noopener\">Journal \/ source \u2197<\/a><\/div><div class=\"jr-license\">\u00a9 2021 the authors. CC BY 4.0. Original preprint PDF; unchanged. <a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" target=\"_blank\" rel=\"noopener\">License<\/a><\/div><\/div><\/article><article class=\"jr-paper\" id=\"research-2018\"><div class=\"jr-year\">2018<\/div><div><div class=\"jr-type\">Retrospective comparative study<\/div><h2>Plate Design and Support in Shoulder Fracture Fixation<\/h2><p class=\"jr-title\">The outcome of surgical management of proximal humeral fractures using locking plates: comparison between locking plates with different geometry<\/p><p class=\"jr-citation\">Chen JL, Chang FC, Lin SJ, Chuang PY, Peng KT, Huang KC, Huang TW. Journal of Shoulder and Elbow Surgery. 2018;27(12):2159-2166.<br>DOI: 10.1016\/j.jse.2018.05.033<\/p><p class=\"jr-summary\">This study compared two locking plate systems in 100 patients with proximal humeral fractures. Radiographic impaction differed between plate designs, and medial calcar support influenced outcomes. However, functional scores did not differ significantly between the groups at the twelve-month assessment. The findings distinguish differences in fixation behaviour from differences in patient function.<\/p><div class=\"jr-links\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1058274618303884\" target=\"_blank\" rel=\"noopener\">Journal \/ source \u2197<\/a><\/div><div class=\"jr-license\">Full text is provided through the original publisher where available.<\/div><\/div><\/article><article class=\"jr-paper\"><div class=\"jr-year\">2018<\/div><div><div class=\"jr-type\">Single-patient case report<\/div><h2>A Vascular Emergency Complicating Hip Joint Infection<\/h2><p class=\"jr-title\">Pseudoaneurysm rupture with hemorrhagic shock in a patient with periprosthetic hip joint infection: A case report<\/p><p class=\"jr-citation\">Chen JL, Yang TY, Chuang PY, Huang TW, Huang KC. Medicine. 2018;97(26):e11028.<br>DOI: 10.1097\/MD.0000000000011028<\/p><p class=\"jr-summary\">This case report describes life-threatening bleeding from an external iliac artery pseudoaneurysm in a patient with chronic hip prosthetic joint infection. Temporary control using an antibiotic-loaded cement spacer allowed subsequent vascular stent-graft repair. The case highlights a rare complication and multidisciplinary management; a single successful case cannot establish a standard treatment for all patients.<\/p><div class=\"jr-links\"><a href=\"https:\/\/www.ovid.com\/jnls\/md-journal\/pdf\/10.1097\/md.0000000000011028~pseudoaneurysm-rupture-with-hemorrhagic-shock-in-a-patient\" target=\"_blank\" rel=\"noopener\">Read original PDF \u2197<\/a><a href=\"https:\/\/www.ovid.com\/jnls\/md-journal\/fulltext\/10.1097\/md.0000000000011028~pseudoaneurysm-rupture-with-hemorrhagic-shock-in-a-patient\" target=\"_blank\" rel=\"noopener\">Journal \/ source \u2197<\/a><\/div><div class=\"jr-license\">Full text is provided through the original publisher where available.<\/div><\/div><\/article><article class=\"jr-paper\" id=\"research-2017\"><div class=\"jr-year\">2017<\/div><div><div class=\"jr-type\">Bibliography entry \u00b7 Full text pending verification<\/div><h2>Osteoporosis Medication and Hip Fractures<\/h2><p class=\"jr-title\">Effects of anti-osteoporosis medications on osteoporotic hip fractures<\/p><p class=\"jr-citation\">Chen JL, Chang FC, Lee CY, Huang TW, Huang KC. Formosan Journal of Musculoskeletal Disorders. 2017;8:154-160. Bibliographic details as listed by the hospital.<br>DOI: 10.6492\/FJMD.20161014<\/p><p class=\"jr-summary\">This publication is listed in Dr. Chen&#x27;s hospital bibliography. The original abstract and full text have not yet been verified, so a summary of its methods and findings is not included. The journal record or an authorised original copy is needed before adding a research summary or PDF download.<\/p><div class=\"jr-links\"><a href=\"https:\/\/www.cgmh.org.tw\/en%29\/Services\/DoctorInfo\/8640\" target=\"_blank\" rel=\"noopener\">Journal \/ source \u2197<\/a><\/div><div class=\"jr-license\">Original abstract and full text are not yet verified.<\/div><\/div><\/article><p class=\"jr-note\">These summaries are an introduction to the research, not individual treatment advice. Preprints and preclinical studies are labelled separately. Study findings should be interpreted in the context of their design and limitations.<\/p><\/section>\n","protected":false},"excerpt":{"rendered":"<p>\u9996\u9801 \u9673\u4fca\u826f\u91ab\u5e2b \u6cbb\u7642\u9805\u76ee \u6700\u65b0\u6d88\u606f \u5e38\u898b\u554f\u984c CHEN JIUN LIANG \u00b7 ORTHOPAEDIC R [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1178","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Research &amp; Publications | Dr. Chen Jiun Liang<\/title>\n<meta name=\"description\" content=\"Explore Dr. Chen Jiun Liang\u2019s orthopaedic research on joint replacement infections, fracture care and bone health, with English summaries and original papers.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/orthojiunliang.tw\/en\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research &amp; 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